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SWI/SNF complex Brg1(I)
Function:
- chromatin remodeling
Structure:
- subunits: SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, & probably HDAC2 & RBAP48
General
SWI/SNF chromatin remodeling complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: transcription activator BRG1
COMPARTMENT: cell nucleus
MOTIF: SS18L1/CREST interaction {1-282}
MOTIF: Thr phosphorylation site {T11}
HSA {460-532}
lysine-rich region {578-588}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T609}
Ser phosphorylation site {S610}
Ser phosphorylation site {S613}
Ser phosphorylation site {S655}
Ser phosphorylation site {S657}
Ser phosphorylation site {S660}
Ser phosphorylation site {S662}
glutamate-rich region {663-672}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S695}
Ser phosphorylation site {S699}
Ser phosphorylation site {S721}
helicase
NAME: helicase
SITE: 766-931
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 779-786
DEAD/H box
NAME: DEAD/H box
SITE: 881-884
Helicase C-terminal {1084-1246}
glutamate-rich region {1360-1364}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1382}
Ser phosphorylation site {S1452}
bromodomain {1477-1547}
MOTIF: peptide motif {1539-1540}
Ser phosphorylation site {S1570}
glutamate-rich region {1571-1584}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1575}
Ser phosphorylation site {S1586}
Ser phosphorylation site {S1627}
Ser phosphorylation site {S1631}
Ser phosphorylation site {S1640}
Ser phosphorylation site {S1642}
Ser phosphorylation site {S1644}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
COMPARTMENT: cell nucleus
MOTIF: binding site
SITE: 106-183
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
MOTIF: Ser phosphorylation site {S129}
binding site
SITE: 183-243
FOR-BINDING-OF: HIV-1 INTEGRASE
tandem repeats {186-319}
MOTIF: consensus repeat {186-245}
binding site
SITE: 186-245
FOR-BINDING-OF: myc protein family
consensus repeat {259-319}
PPP1R15A interaction {304-318}
actin-like protein 6A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S233}
actin-like protein 6B
COMPARTMENT: cell nucleus
MOTIF: domain {39-82}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 5-65
MOTIF: proline residue (SEVERAL)
HMG box
SITE: 66-134
coiled coil {220-319}
MOTIF: Ser phosphorylation site {S265}
glutamate-rich region {320-411}
MOTIF: glutamate residue (SEVERAL)
BAF60
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
COMPARTMENT: cell nucleus
MOTIF: multiple interactions {43-167}
MOTIF: lysine-rich region {124-127}
MOTIF: lysine residue (SEVERAL)
SMARCC1/SMARCC2 interaction {168-474}
domain {180-515}
MOTIF: SWIB {291-390}
coiled coil {412-440}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T142}
SWIB {232-307}
Thr phosphorylation site {T408}
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S178}
SWIB {259-334}
SWI/SNF complex subunit SMARCC1
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S301}
Ser phosphorylation site {S310}
Ser phosphorylation site {S319}
Ser phosphorylation site {S328}
proline-rich region
SITE: 329-336
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S330}
Thr phosphorylation site {T335}
Thr phosphorylation site {T337}
Ser phosphorylation site {S339}
Ser phosphorylation site {S357}
SWIRM {449-546}
Ser phosphorylation site {S573}
SANT {618-669}
glutamate-rich region {769-863}
MOTIF: glutamate residue (SEVERAL)
alanine-rich region {867-878}
MOTIF: alanine residue (SEVERAL)
coiled coil {914-946}
proline-rich region
SITE: 977-1105
MOTIF: proline residue (SEVERAL)
SWI/SNF complex subunit SMARCC2
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {186-189}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S283}
Ser phosphorylation site {S286}
Tyr phosphorylation site {Y296}
Ser phosphorylation site {S302}
Ser phosphorylation site {S304}
Ser phosphorylation site {S306}
Thr phosphorylation site {T322}
Ser phosphorylation site {S347}
SWIRM {424-521}
SANT {596-647}
glutamate-rich region {747-855}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S806}
Ser phosphorylation site {S810}
alanine-rich region {861-870}
MOTIF: alanine residue (SEVERAL)
coiled coil {907-934}
glutamine-rich region {956-960}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 961-1213
MOTIF: proline residue (SEVERAL)
AT-rich interactive domain-containing protein 1A
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S79}
Ser phosphorylation site {S233}
Thr phosphorylation site {T286}
LXXLL {295-299}
Ser phosphorylation site {S363}
Ser phosphorylation site {S382}
glutamine-rich region {479-482}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {561-567}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S604}
Ser phosphorylation site {S696}
Ser phosphorylation site {S698}
Ser phosphorylation site {S702}
Ser phosphorylation site {S764}
Ser phosphorylation site {S772}
serine-rich region {998-1001}
MOTIF: serine residue (SEVERAL)
ARID {1017-1108}
Ser phosphorylation site {S1184}
glutamine-rich region {1327-1404}
MOTIF: glutamine residue (SEVERAL)
LXXLL {1709-1713}
Ser phosphorylation site {S1755}
Ser phosphorylation site {S1944}
LXXLL {1967-1971}
LXXLL {2085-2089}
paired amphipathic helix protein sin3a
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S10}
HCFC1 interaction {119-196}
MOTIF: paired amphipathic helix {119-189}
REST interaction {205-480}
MOTIF: proline-rich region
SITE: 218-285
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S277}
Ser phosphorylation site {S289}
paired amphipathic helix {300-383}
paired amphipathic helix {456-525}
MOTIF: SAP30 interaction {458-525}
NCOR1 interaction {523-850}
MOTIF: SUDS3/SAP130 interaction {524-659}
HDAC1/ARID4B interaction {687-829}
Ser phosphorylation site {S832}
glutamate-rich region {835-841}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S860}
OGT interaction {888-967}
MOTIF: coiled coil {903-932}
Ser phosphorylation site {S940}
Ser phosphorylation site {S1108}
Ser phosphorylation site {S1112}
histone deacetylase 2
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-322}
MOTIF: histidine residue {H142}
glycine-rich region {300-303}
Ser phosphorylation site {S394}
Ser phosphorylation site {S407}
Ser phosphorylation site {S422}
Ser phosphorylation site {S424}
histone-binding protein RBBP4
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {122-155}
WD repeat {175-206}
WD repeat {225-256}
WD repeat {271-302}
WD repeat {315-346}
WD repeat {372-403}
References
UniProt :accession O14497
Components
actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)
actin-like protein 6B; 53 kD BRG1-associated factor B; actin-related protein Baf53b; ArpNalpha; BRG1-associated factor 53B; BAF53B (ACTL6B, ACTL6, BAF53B)
AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270; B120; SWI-like protein; Osa homolog 1; hOSA1; hELD; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A (ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1)
histone deacetylase 2 (HDAC2)
histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48)
paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; integrase interactor 1 protein; SNF5 homolog; hSNF5; BRG1-associated factor 47; BAF47 (SMARCB1, BAF47, INI1, SNF5L1)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; SWI/SNF complex 60 kD subunit; 60 kD BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A (SMARCD1, BAF60A)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; 60 kD BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B (SMARCD2, BAF60B, PRO2451)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; 60 kD BRG-1/Brm-associated factor subunit C; BRG1-associated factor 60C; BAF60C (SMARCD3, BAF60C)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BRG1-associated factor 57; BAF57 (SMARCE1, BAF57)